hrp0094p2-280 | Growth and syndromes (to include Turner syndrome) | ESPE2021
AL Jorge Alexander
, Pietropoli Alberto
, Kelepouris Nicky
, Horikawa Reiko
,
Objectives: Mutations in PTPN11 are known to be associated with Noonan syndrome (NS), accounting for approximately 50% of cases. Data from a non-interventional and phase 3 study of Norditropin (somatropin; Novo Nordisk A/S, Denmark) were used to assess the impact of PTPN11 mutation status on growth outcomes in children with NS receiving growth hormone therapy (GHT).Methods: The ANSWER (NCT01009905) prog...